University of Birmingham researchers used living human brain tissue to show that blocking a receptor called P2X7 sharply curbs neuroinflammation — a preclinical finding the team says could speed existing drugs toward trials.
A University of Liverpool-led trial found adults lost comparable weight whether they drank diet beverages or plain water over two years, challenging cautious WHO guidance on artificial sweeteners.
A Johns Hopkins study in lab-grown lung organoids and mice finds that smoke exposure has to come before a cancer mutation — not the other way around — for tumors to form, with different mutations steering cells toward different cancers.
More than 1,000 cases, nearly 200 hospitalizations and five deaths have been tied to an outbreak that took hold where childhood vaccination rates had slipped below the level needed to stop the virus from spreading.
Scientists at King's College London found that a compound produced from eating pomegranates, walnuts and berries improved heart function in lab studies, offering a new lead against a common, hard-to-treat form of heart failure.
An analysis of 1.4 million volunteers found more than a third have hypertension — and most of those cases go undiagnosed or poorly controlled, researchers reported.
A small but carefully controlled study found that coffee, caffeinated or not, reshapes gut bacteria in ways tied to mood, memory and attention.
A study of more than 100,000 U.K. adults found that walking briskly can offset a low daily step count, though the researchers stress their data show correlation, not proof that pace itself extends life.
A Cleveland Clinic trial of a one-time CRISPR gene-editing infusion kept cholesterol and triglycerides sharply lower a year later, but the study enrolled just 15 patients and was funded by the drug's maker.
A deep-learning model screened millions of compounds to flag two early-stage antibiotic candidates that killed drug-resistant gonorrhea bacteria in lab and animal tests, though human trials are still years away.
An analysis of a long-running U.S. heart study found adults who ate the most ultra-processed food had a substantially higher risk of heart attack, stroke and related events than those who ate the least, with the gap widest among Black participants.
Weill Cornell and HSS researchers found a stem cell that, when overactive, drives the ligament overgrowth behind lumbar spinal stenosis — and point to an existing blood-pressure drug class as a possible way to calm it.
A 400-person study presented at a major diabetes conference found people felt better the day after wider — but still safe — glucose swings, raising questions about how rigid glucose control should be.
A three-month study of 204 Canadian couples found a sleepless partner's habits ripple into the other's eating, even when both are trying to eat better.
The newly identified Asian longhorned tick nairovirus turned up in one of every ten feverish tick-bite patients tested, and turned deadly mainly when paired with a virus doctors already watch for.
A 12-week Texas A&M trial found middle-aged adults gained lean muscle on creatine alone — and gained even more when they paired it with exercise and a calorie-reduced diet.
A South Korean randomized trial found that common blood thinners sharply lowered strokes and other serious events in atrial fibrillation patients previously seen as too low-risk to treat routinely — though the open-label design and small number of events call for caution.
King's College London researchers found urolithin A, made by gut bacteria after eating pomegranates and walnuts, improved heart relaxation by up to 80% in models of heart failure with preserved ejection fraction.
Federal health officials urged consumers to discard Sierra Nevada Graziers raw milk cheeses after three children developed a severe kidney complication linked to the recalled products.
A 27-year analysis of the Cincinnati region found first-time strokes among 20-to-54-year-olds climbing sharply, driven mostly by clot-related strokes even as short-term survival improved.
An analysis of nearly 96,000 wrist-accelerometer users found more time in dream sleep was tied to a lower risk of 83 conditions, from dementia to heart failure.
A divided advisory vote endorses Galleri screening for adults 50 and older, even though its lead study didn't show fewer late-stage diagnoses or a mortality benefit.
With outbreaks in 47 jurisdictions and vaccination rates sliding, health researchers say the country is on track to lose the measles elimination status it has held since 2000.
A 20-year analysis of more than 113,000 Ontario patients found that transient ischemic attacks raise long-term dementia risk by about a third, with the danger persisting well beyond the initial event.
Four measles deaths in Pennsylvania's Amish country have triggered a nurse-led vaccination push — and a political fight over the federal health secretary's role.
A nine-year tracking study of nearly 95,000 adults found that people who got more REM sleep faced lower odds of dozens of conditions, from heart failure to dementia and Parkinson's.
ARPA-H's new SPECTRA initiative aims to move autism research beyond childhood behavioral screening toward tools that follow individuals from early diagnosis into adulthood.
The GRAIL-funded PATHFINDER 2 trial found its Galleri blood test caught early-stage cancers often missed by routine screening, but researchers caution it is a complement, not a replacement, for standard checkups.
PET scans of 24 patients tie apathy, slowed movement and memory trouble to measurable damage in dopamine-producing brain circuits.
Researchers found cardiovascular risk climbs steadily the longer patients stay off GLP-1 drugs, reaching 22 percent higher within two years of quitting.
An analysis of more than 333,000 U.S. veterans with type 2 diabetes found cardiovascular risk climbed the longer patients went without semaglutide-class medications after starting them.
A systematic review of nearly 154,000 older adults across 69 trials found little to no benefit from routine calcium or vitamin D supplementation, prompting calls to revisit guidelines.
A Swedish registry study of more than 7,000 patients found modestly slower memory decline among those on newer anticoagulants than on warfarin — but the observational design leaves the cause unproven.
More than 650 infections have been confirmed in Italy this year, about half of all cases in Europe, as researchers link longer, hotter mosquito seasons to the virus's expanding reach.
Children as young as 4 with activated PI3K-delta syndrome can now access leniolisib, though the pediatric approval rests heavily on a small dosing study of just eight patients rather than a new efficacy trial.
Clinics across the U.S. are offering low-intensity shockwave therapy, borrowed from kidney-stone treatment, for erectile dysfunction — though the FDA hasn't approved it and major urology groups say the evidence remains thin.
Curium's Bexlutry becomes the first approved alternative to Lutathera for somatostatin receptor-positive neuroendocrine tumors, a move the company says will bolster supply of the specialized cancer treatment.
In a small trial, healthy men who sniffed dark chocolate before and during a fasted leg workout squeezed out roughly 18 more repetitions than those who smelled water — without feeling any more exhausted.
A meta-analysis pooling 87 clinical trials found measurable improvements in weight, blood pressure, cholesterol and inflammation at moderate whole-grain intake, though researchers caution the trials were short and don't prove fewer heart attacks.
An analysis of UK medical records found semaglutide users had nearly 40 percent fewer asthma attacks and a fifth fewer COPD flare-ups than those on an older diabetes drug — but researchers stress the findings are observational, not from a randomized trial.
A review of 1.9 million people found gastrointestinal symptoms nearly 50 percent more common among those with ADHD, though researchers stress the data show an association, not proof that one condition causes the other.
A 24-hour skin patch caught nighttime bursts of a blood-pressure hormone that routine blood tests miss, offering a possible new way to diagnose primary aldosteronism.
An unvaccinated 40-year-old woman with underlying lung disease died in Jefferson County as the state's case count topped 690 and the national tally reached its highest level since 1991.
A 13-year study of nearly 7,000 seniors found high waist circumference raised mortality risk by 24 percent, even as higher BMI was linked to a survival edge researchers call a statistical paradox, not proof that extra weight helps.
A world-first study out of the University of Sydney found living human heart tissue producing new muscle cells after a heart attack, a discovery researchers hope could eventually lead to therapies for heart failure.
Federal officials closed out the largest cyclospora outbreak on record, linked to Taylor Farms de Mexico iceberg lettuce, even as the source of the contamination remains unconfirmed.
Meena Geltink and Minal Tijssen bonded as Mumbai-born teenagers in the Netherlands and joked about being 'sisters' for years — then a DNA test proved it.
A study of nearly 74,000 men found tadalafil users had a 22% higher glaucoma risk than non-users, prompting calls for baseline eye exams rather than a change in prescribing.
Cedars-Sinai researchers say a checkpoint protein called PD-L2 helps damaged cells evade immune clearance, offering a new target for anti-aging therapies still confined to mice.
A Danish study found smaller ovaries and wombs in infant girls exposed to the painkiller before birth, but outside statisticians say the evidence is too weak to change medical guidance.
An analysis of more than 80,000 patient records found semaglutide was linked to roughly 40 percent fewer asthma attacks and 20 percent fewer COPD exacerbations than other diabetes treatments, but researchers say the observational data are not yet grounds to prescribe the drug for lung disease.
CDC data show infections growing or likely growing in 47 states, with Texas reporting the highest wastewater levels, as the country's now-familiar twice-yearly surge pattern repeats.
The largest primary-prevention statin trial in older adults found a 30 percent drop in major cardiovascular events — but no gain in disability-free years.
A study of aging's most extreme survivors found a rare immune cell that multiplies dramatically the older people get — and may help explain their resistance to disease.
A detailed cell-by-cell map of breast tumors found that dormant cancer cells cluster in neighborhoods ringed by protective immune and connective-tissue cells — a possible explanation for why cancer can return years after treatment ends.
In mice, liver cells injected alongside tiny hydrogel spheres formed working tissue that survived for two months and produced many of the proteins a healthy liver makes — an early step toward supplementing, not replacing, a failing organ.
Aged mice fed high doses of a lipid abundant in the ocean-dwelling filter feeders regrew darker fur, sharpened memory and calmed inflamed brain cells — though scientists caution the leap to humans remains untested.
First joint ESC-European Renal Association guidelines call for blood and urine testing at diagnosis, reflecting new evidence that heart and kidney disease accelerate each other.
A phase 3 trial found the once-nightly drug AD109 cut breathing interruptions by 44 percent, though it is not yet FDA-approved and roughly a fifth of participants stopped taking it due to side effects.
Camizestrant is the first cancer drug the FDA has approved based on a resistance mutation caught in the bloodstream before imaging shows a tumor has progressed.
The Ig Nobel Prize's medicine award went posthumously to a Japanese otolaryngologist whose 1977 study settled, with aerodynamic rigor, the correct way to blow one's nose.
Zanvastro, an antisense drug from Ionis Pharmaceuticals, stabilized walking speed in a pivotal trial for the ultra-rare, fatal neurological disorder that has never before had a targeted therapy.
A peer-reviewed Science study from MD Anderson found psilocybin prevented chemotherapy-induced nerve injury in preclinical models without blunting the drugs' tumor-killing effect — a mouse-model finding now moving into a Phase 2 human trial.
The LifeAfter90 cohort study of more than 800 people found women and Black participants faced markedly higher dementia risk even after reaching 90 — an observational finding researchers say reflects both genetics and lifelong health disparities.
The STAREE trial found daily atorvastatin reduced cardiovascular events in older adults without prior heart disease — but it didn't extend disability-free years, complicating how doctors should use the results.
In animal models and human spinal cord tissue, researchers found that the cancer protein BRAF migrates to the spinal cord after nerve injury and amplifies pain signals, and that cancer drugs already on the market blocked the effect.
Men already genetically prone to male-pattern baldness face a 7% added risk of hair loss when using drugs like Ozempic, Wegovy and Zepbound, according to a new genetic analysis that is the first to move beyond anecdotal reports.
A five-month trial that controlled participants' meals found a keto diet cut liver fat and reversed prediabetes more often than a Mediterranean or low-fat plant-forward diet, despite similar weight loss across all three groups.
A randomized crossover trial near a Massachusetts highway found faster executive-function test times after a month of real HEPA filtration versus a sham device — with limitations the authors are candid about.
A five-year analysis of more than 130,000 insomnia patients found nearly double the heart failure rate among long-term melatonin users, though researchers stress the finding is preliminary and not proof of cause.
A mouse study found that sucralose and stevia altered gut bacteria and gene activity in ways that echoed into a second generation that never tasted either sweetener.
A 60-person randomized, placebo-controlled study run inside Britain's public health system found large reductions in depressive symptoms after one supervised psilocybin session, though researchers caution larger trials are still needed.
More than 2,700 confirmed cases and a slipping childhood vaccination rate have pushed the country to the brink of losing a status it has held since 2000.
A postmortem analysis of nearly half a million hippocampal cells found disrupted neuron formation in people who had major depression, offering the first cell-level evidence for a long-suspected piece of the disorder's biology.
A seven-year analysis of more than 72,000 older adults found that people who received the newer Shingrix shot had less cardiovascular disease than those given its predecessor, though researchers say a randomized trial is still needed to confirm cause and effect.
An analysis of half a million hippocampal brain cells ties major depressive disorder to disrupted new-neuron formation, though the researchers stress the postmortem data show correlation, not causation.
A 20-day pilot study of 40 adults with mildly elevated blood pressure found peppermint oil capsules modestly reduced systolic readings, though researchers caution the trial was small and short.
Federal health officials say a multistate parasite outbreak linked to iceberg lettuce from a Mexico-based supplier has sickened nearly 11,000 people and hospitalized hundreds since the spring, even as the recalled product has cleared store shelves.
A decade-long analysis of nearly 29,000 British patients found women more often develop mental health conditions after a diabetes diagnosis, while men more often develop heart and kidney disease.
A four-year analysis of more than 500,000 older Medicare patients found fewer dementia diagnoses among those vaccinated against shingles — but the study's authors say it cannot prove the shot is the cause.
Two unvaccinated Lancaster County residents died as Pennsylvania's outbreak grew, part of the worst national measles year since 1991.
An analysis of prescription records and stool samples from 2,509 Estonians found nearly half of the medications tested left detectable changes in gut bacteria long after people stopped taking them.
A Singapore birth-cohort study tracking 502 children found screen exposure in infancy, and again around school entry, predicted weaker working memory and academic performance years later.
A Basque Country study used AI-read brain scans to show each added language tracked with a younger-looking brain — with the biggest gains for early, fluent learners.
Older adults carrying a specific gut microbe had notably stronger grip strength, and the same bacterium boosted muscle in mice — though researchers say human trials of any treatment are still years away.
New CDC data show the country's largest measles caseload in more than three decades, with a review this year set to determine whether the U.S. keeps its disease-free status.
Urolithin A, a compound made in the gut from foods like pomegranates and walnuts, improved heart relaxation and reduced scarring in animal and engineered-tissue models, King's College London researchers report.
A 20-day placebo-controlled trial found a twice-daily peppermint oil supplement cut systolic blood pressure by roughly 8.5 points in adults with mildly elevated readings.
Confirmed cases have climbed past 2,700 for the year, the highest count since the disease was declared eliminated in 2000, with the CDC reporting the vast majority of patients unvaccinated.
A Rockefeller University study finds brief, all-out cycling sprints trigger sweeping molecular changes in blood tied to disease protection, dwarfing the effect of a much longer moderate workout.
GDF15, the hormone tied to drugs like semaglutide, suppressed liver inflammation and scarring in mice through a newly identified brain-to-liver pathway -- independent of any weight loss.
Falling childhood vaccination rates are driving the country's largest measles resurgence since the disease was declared eliminated in 2000, CDC data show.
McMaster University researchers found that GDF15, best known for suppressing appetite, also signals the brain to calm liver inflammation independent of weight loss.
A multistate Cyclospora outbreak traced to iceberg lettuce from a single Mexican processor has now sickened 10,930 people and killed two, according to CDC's latest update.
Stanford researchers traced bone marrow-derived immune cells settling into the human brain during aging — a pattern not seen in mice, with possible ties to Alzheimer's risk.
A modified probiotic strain colonizes low-oxygen tumors and switches on the immune system, slowing pancreatic cancer growth in animal studies.
An analysis of more than 21,000 women found lower odds of dementia diagnosis and less amyloid buildup among past users of estrogen-only therapy, though researchers caution the finding is not proof of prevention.
A Stanford analysis of more than 21,000 women found less brain pathology and fewer dementia diagnoses among estrogen-only users, though researchers caution the study can't prove cause and effect.
Structure Therapeutics' oral GLP-1 candidate helped patients shed up to 12% of body weight in 36 weeks, setting up pivotal trials.
The long-running PANIC study out of the University of Jyväskylä found more childhood screen time was linked to sharper cognitive processing in adolescence, though researchers caution the finding is an association, not proof of benefit.